Luis Enrique said on Saturday that Busquets "isn't 100 percent but he will be there" for the clash against Barcelona's fierce rival and biggest challenger for the Spanish league title.
Busquets has been sidelined for the last three games since injuring his right ankle against Villarreal in the Copa del Rey.
Javier Mascherano has played in his place and would do so again against Madrid if Busquets isn't fit.
Barcelona leads the league by one point over Madrid.
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