BOSTON — Houston starter Brad Peacock lasted long enough against Boston this time to blow a sizable lead.
Peacock gave up a pair of two-run homers to David Ortiz, including the slugger's 400th in a Red Sox uniform, that powered Boston past the Astros 10-7 on Saturday night.
Peacock gave up six runs in 4 1-3 innings. On July 13 at Minute Maid Park, he retired just one batter before being pulled with the bases loaded and the score tied at 1 when Houston lost to Boston.
"Our offense did a great job for me tonight and I just couldn't back them up," he said. "I felt good tonight. I felt like the fastball was coming out good, just the offspeed stuff killed me. Made some bad two-strike pitches."
Houston manager Bo Porter stuck with Peacock as long as he could, but knows the young right-hander needs to pitch further into games.
"We're going to definitely need him to get deeper into the game and stop putting that kind of stress on the bullpen," he said. "It's something that needs to be rectified."
Big Papi joined Hall of Famers Ted Williams and Carl Yastrzemski as the only players to hit 400 homers while playing with the Red Sox. Ortiz did it with his shot into the first row of the center-field seats in the third inning.
"David Ortiz is a Hall of Famer. He's about as good as it gets in this game," Porter said.
Chris Carter hit a solo homer and added a sacrifice fly for the Astros, who lost for the fifth time in seven games. A day earlier, Houston collected the franchise's first win in Fenway Park after going 0-8.
Ortiz hooked his other homer around the Pesky Pole in right in the fifth. He has 459 home runs in his career, which started with Minnesota.
Ortiz added a two-run double in the eighth, matching his career high with six RBIs. He left to a standing ovation for a pinch runner, tipping his helmet as the crowd gave him a curtain call.
Williams hit 521 homers and Yaz had 452. Both spent their entire careers with the Red Sox.
Alex Wilson (1-0) earned the win with 2 1-3 hitless innings.
The Astros built a 5-1 lead against Rubby De La Rosa by scoring two in the first, one in the second and two in the third.
After Ortiz's first homer cut Houston's lead to 5-3, Carter homered over the Green Monster in the fourth.
WELL EARNED DAY OFF
Astros 3B Matt Dominguez, who entered the day tied for the most games played in the majors, was rested Saturday. "We were going to go for (Cal) Ripken's record, but figured we'd go ahead and cut it short right now. We'll start another one tomorrow and probably catch him," Porter said, joking before explaining he needed rest.
Astros: Porter said OF Alex Presley (strained right oblique) will be shut down for "seven to 10 days" after feeling discomfort during his minor league rehabilitation assignment at Tri-City of the New York-Penn League. Porter also said LHP Darin Downs, dealing with oblique soreness but still on the active roster, will "need a couple of more days."
Red Sox: 2B Dustin Pedroia was back in the lineup after leaving Friday's game after fouling a ball off his right foot. OF-1B Allen Craig, on the DL with a sprained left foot, is expected to start a rehab assignment, beginning Monday with Triple-A Pawtucket. He did some running during BP with a member of the team's medical staff watching. C David Ross (plantar fasciitis) is expected to be activated early next week.
RHP Collin McHugh (5-9, 3.08 ERA) is scheduled for Houston on Sunday. RHP Joe Kelly (0-0, 2.08) is slated to make his Fenway debut with the Red Sox. He was acquired at the non-waiver trade deadline from St. Louis along with Craig for RHP John Lackey.
The Red Sox had a moment to honor Maj. Gen. Harold "Harry" J. Greene, who was killed in Afghanistan earlier this month. He was born in Boston and a big Red Sox rooter. His family wore Red Sox jerseys and stood on top of their dugout when his picture was shown in the center-field scoreboard after the fifth inning. They received a standing ovation. Greene, the highest-ranking U.S. military officer killed in combat since the Vietnam War, was buried with full honors Thursday at Arlington National Cemetery.