Defending champion Ajax also won easily, beating Utrecht 3-1 to stay second.
De Jong opened the scoring for PSV against his former team, heading in a corner in the 21st minute. Wijnaldum doubled the lead on the stroke of halftime, finishing off a slick passing move from close range.
Midfielders Thulani Serero and Davy Klaassen and winger Anwar El Ghazi scored for Ajax in the Amsterdam Arena.
PEC Zwolle moved third by beating Willem II 1-0 in Tilburg on Saturday night.
Alkmaar went 2-0 up in the first half before Feyenoord clawed its way to a point thanks to an injury-time equalizer from midfielder Jordy Clasie.
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