Seimone Augustus added 12 points and Moore had nine rebounds for the Lynx (9-3) who built a 50-28 lead after opening the third quarter on an 11-2 run.
The Stars (3-10) missed their first nine field-goal attempts of the game as Minnesota opened on 15-2 run. The Lynx led by no less than 11 the rest of the way.
Dearica Hamby scored 13 points and Kayla Alexander grabbed 11 rebounds to lead San Antonio, which has lost four of its last five.
The top-ranked Lynx defense's 49 points allowed was a season best coming off a season-worst effort in Friday's 90-83 loss at Chicago.