Tests confirmed right-hander Wily Peralta is expected to miss four to six weeks because of a strained oblique on his left side. He was hurt while pitching Friday night in Atlanta.
The Brewers recalled right-hander David Goforth, but did not announce a starter for Peralta's turn in the rotation on Wednesday.
"I didn't think I'd be on the DL," Peralta said. "Four to six weeks is a long time to be out. It's tough."
Peralta is 1-5 with a 4.00 ERA in nine starts this year.
While those numbers aren't great, Milwaukee's entire starting staff has a total of just nine victories and carries a 4.77 ERA.
Against the Giants, the worst team in the majors at 16-30 fizzled following a 4-1 lead and a bizarre early sequence.
Khris Davis was called out for missing the plate on his home run trot, then it wound up counting after Milwaukee challenged the ruling.
In the first inning, Davis pointed in the crowd in celebration and skipped across the plate. It appeared to both umpire Will Little and Giants catcher Andrew Susac that the back of Davis' right foot failed to touch down on the dish.
"I knew he didn't," said Susac, who stood next to Little for a close-up view as Davis came by. "The thing was, I asked the umpire, you know I know he's not going to tell me whether he knows or not, but I said as soon as he did it, 'It looked like he missed it.'"
Giants manager Bruce Bochy came out of the dugout before the out call. Brewers manager Craig Counsell then walked onto the field to contest the decision.
"There ended up being an appeal, then we challenged it," Counsell said. "It's as simple as that, really."
Davis hit two home runs, but was in no mood to talk about the odd sequence. He repeated several different variations of the same phrase to deflect attention away from the play.
"It's not about me, it's about the team," he said.
Lincecum (5-2) wasn't as effective as his previous three starts, giving up Davis' two homers and a tape-measure shot to Braun, but earned a win thanks to San Francisco's seven-run sixth.
Braun hit a 474-foot homer in the fifth. The two-run shot was the fourth longest in Miller Park history and cleared the left field bleachers. It gave Milwaukee a 4-1 lead, but the Brewers unraveled the following inning.
"The game started off good but then got away from us. It's a huge momentum shifter," Braun said. "It seems like we've been on the wrong side of too many of those innings as of late."
Kyle Lohse (3-5) took the loss.
Giants: Susac started in place of Buster Posey, who was given a day off.
Brewers: Counsell said SS Jean Segura (broken finger) will be activated on Friday when his stint on the 15-day disabled list ends. .. Brewers C Jonathan Lucroy (broken toe) said he's been cleared for full baseball activity, so he's aiming to return in a week at the start of Milwaukee's next road trip.
Giants: Ace Madison Bumgarner (5-2, 2.84 ERA) starts the second game of the series against the Brewers. The 25-year-old left-hander is 4-2 with a 1.65 ERA in seven games against Milwaukee, and even better in Miller Park with just one earned run allowed over 15 2-3 innings.
Brewers: Matt Garza (2-6, 5.71) starts against Bumgarner. While Garza has had a season to forget so far, against current San Francisco hitters, he's held them to a combined .203 average with one home run and 12 strikeouts over 64 at-bats. The lone homer was by Aoki, who is 1 for 11 in his career against Garza.
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