Holliday, the third batter in Wednesday's game, was hit on the left elbow by a 94 mph fastball. He backed away from the plate after being hit, removed his helmet and fell to one knee in pain.
Cardinals manager Mike Matheny and a trainer checked on Holliday, who slowly walked to first base.
Holliday remained in the game temporarily, but was replaced in left field by Pete Kozma in the second inning.
Cardinals pitcher John Lackey hit Jason Kipnis in the back in the fourth inning. Plate umpire Mike Everitt issued warnings to both teams, which led to the ejection of Indians manager Terry Francona, who vehemently argued with Everitt and crew chief Tim Welke.
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