The Chippewas (20-5, 10-4 Mid-American) won their fifth game in a row and moved into a first-place tie in the West Division of the MAC.
Up just two early in the second, the Chippewas scored 38 of the next 52 points. Central Michigan outscored the Cardinals 42-24 in the second half.
Ball State coughed up 13 turnovers while Central Michigan had just four.
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